Search results for "breast cancer patient"

Gene ontology-based annotation and comparative analysis of proteins extracted from proteomics of 100 breast cancer patients.

2009

Background: Current clinical parameters for breast cancer diagnosis and therapy are: tumour size, axillary lymph node status, histological grading and presence or absence of metastases. Prognostic/predictive properties, such as oestrogen and progesterone receptor status, and human epidermal growth factor receptor (HER-2/neu) status are currently used for therapeutic decision. Conversely, it is now emerging that the number of genetic mutations and epigenetic deregulations in cancer is far more higher than previously thought. Therefore, proteomic screening for differential protein expression in subsets of tumor samples is an essential tool for generating data bases and biomarker discovery. Th…

Osteonecrosis of the jaw (ONJ) risk in breast cancer patients after zoledronic acid treatment

2010

The importance of adoption of recommendations for ONJ prevention strategy will notably grow for zoledronic acid in the next future, in view of possible further enlargement of its indications (even with different timing and schedules) in breast cancer patients without bone metastases (such as in adjuvant and neo-adjuvant settings, and in hormonotherapy-induced osteopenia

In vivo manipulation of Vgamma9Vdelta2 T cells with zoledronate and low-dose interleukin-2 for immunotherapy of advanced breast cancer patients.

2010

The potent anti-tumour activities of gamma delta T cells have prompted the development of protocols in which gamma delta-agonists are administered to cancer patients. Encouraging results from small Phase I trials have fuelled efforts to characterize more clearly the application of this approach to unmet clinical needs such as metastatic carcinoma. To examine this approach in breast cancer, a Phase I trial was conducted in which zoledronate, a V gamma 9V delta 2 T cell agonist, plus low-dose interleukin (IL)-2 were administered to 10 therapeutically terminal, advanced metastatic breast cancer patients. Treatment was well tolerated and promoted the effector maturation of V gamma 9V delta 2 T …

A combined determination of circulating gelatinases and inflammatory markers in breast cancer patients during therapeutic treatment

2008

Spousal support and illness acceptance in breast cancer patients: the mediating function of meaning in life and sense of coherence

2023

The explanation as to why married cancer patients are characterised by better adjustment to illness than unmarried patients is not fully understood. This article aims to investigate a parallel mediation effect of meaning in life and sense of coherence in the relationship of spousal support and illness acceptance in breast cancer patients. A total of 213 wo­men were included in this study. The Berlin Social Support Scales, the Personal Meaning Profile, the Sense of Coherence Scale, and the Acceptance of Life with the Disease Scale were used. Pearson’s correlation coefficient and mediation analysis were performed. The results showed significant correlations between spousal support, meaning in…